His earlier work was noticed by Professor Hugo Strange, who experimented with Tetch's formulas and techniques and found them quite efficacious. Equally impressive, he found ways to incorporate mind-control devices into the hats he made and wore, to both augment his own talents and to render others more susceptible to his influence.

He took his knowledge of hypnotism and psychoactive drugs and began bending the minds of other people. He thought himself the incarnation of the Mad Hatter from Alice in Wonderland, and took up hatmaking as a trade, and, even more disturbing, became a serial killer, marking a girl as 'Alice', luring them away and then killing them. Unfortunately - or perhaps not - Jervis soon descended into mental instability himself. He set forth the basics of a formula which he hypothesized would enable someone to re-write another person's attitudes. He theorized that all of a person's emotions and loyalties could be altered and even controlled with the right chemicals. Jervis Tetch is - or was - a brilliant neuroscientist with some revolutionary ideas on the subject of brain chemistry and free will.

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